ABT-888 (Veliparib): Potent PARP1/2 Inhibitor for Cancer ...

2026-01-20

ABT-888 (Veliparib) is a highly selective poly (ADP-ribose) polymerase (PARP) inhibitor that sensitizes cancer models—especially those with microsatellite instability—to chemotherapy and radiation. Its robust DNA repair inhibition profile and in vivo efficacy make it a reference tool for research in DNA damage response pathways.